Chemical IncompatibilityCAS 7681-52-9
What Not to Mix With Bleach — Chlorine, Chloramine & Other Hazards
Household and laboratory bleach (sodium hypochlorite) reacts dangerously with several common chemicals, releasing toxic gases. Each combination below is a documented incompatibility with its source rule.
Signal word — DANGER
Documented incompatibilities
Sodium hypochlorite + Ammonia
incompatible
Hypochlorite/bleach + ammonia/alkaline solutions releases toxic chloramine gas (NH₂Cl); never mix
Source: GHS Reactive Group Rule · lit:hypochlorite-ammonia-chloramine · Full page for this pair
Sodium hypochlorite + Acetic acid
incompatible
Weak acid (e.g. vinegar, citric) + hypochlorite/bleach releases toxic chlorine gas (Cl₂); never mix
Source: GHS Reactive Group Rule · CAMEO:1x44-acid-hypochlorite-chlorine-gas · Full page for this pair
Hydrochloric acid + Sodium hypochlorite
incompatible
Strong acid + hypochlorite/chlorine-releasing compound releases toxic chlorine gas (Cl₂); never mix
Source: GHS Reactive Group Rule · CAMEO:1x44-acid-hypochlorite-chlorine-gas · Full page for this pair
Sulfuric acid + Sodium hypochlorite
incompatible
Strong acid + hypochlorite/chlorine-releasing compound releases toxic chlorine gas (Cl₂); never mix
Source: GHS Reactive Group Rule · CAMEO:1x44-acid-hypochlorite-chlorine-gas · Full page for this pair
GHS profile of the shared chemical
| Code | Hazard statement |
|---|---|
| H315 | Causes skin irritation |
| H318 | Causes serious eye damage |
| H410 | Very toxic to aquatic life with long lasting effects |
Precautionary statements
- P264 Wash hands thoroughly after handling
- P273 Avoid release to the environment
- P280 Wear protective gloves/protective clothing/eye protection/face protection
- P302 IF ON SKIN
- P305 IF IN EYES
- P332 If skin irritation occurs
- P362 Take off contaminated clothing
- P391 Collect spillage
- P501 Dispose of contents/container in accordance with local regulations
SDS safety rules
Incompatibilities
- Incompatible with acids.Involves: Acids
Storage requirements
- Keep container tightly closed in a dry and well-ventilated place.
Rules extracted from the referenced SDS.
Verified source
- Source
- Official SDS (canonicalized)
- Supplier
- Sigma-Aldrich
- SDS revised
- 2017-11-06
- Last verified
- 2026-08-17
This information is provided for reference purposes only. For critical safety decisions, always consult the official Safety Data Sheet (SDS) and your local regulatory authority. MSDS Chain makes no warranty as to completeness or fitness for a particular purpose.